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New Positive Allosteric Modulator of AMPA Receptors: in vitro and in vivo Studies

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

A new derivative of 3,7-diazabicyclo[3.3.1]nonane, which showed a high activity as a positive allosteric modulator of AMPA receptors of the CNS, was studied in electrophysiological experiments. At doses of 0.01 mg/kg, this compound significantly improved the memory of experimental animals disturbed by maximal electric shock. The results indicate that this compound is a promising candidate for preclinical trials and clinical studies as a drug for treatment of a number of psychoneurological diseases.

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ACKNOWLEDGMENTS

In this study, we used the equipment of the Core Facility of the Institute of Physiologically Active Compounds, Russian Academy of Sciences ​​(Agreement no. 14.621.21.0008, study ID RFMEFI62114X0008).

Funding

This study was supported by the State Assignment of the Institute of Physiologically Active Compounds, Russian Academy of Sciences (theme “The Search for and Study of the Mechanisms of Action of Neuroprotective Agents and Cognitive Stimulants,” state registration no. 0090-2017-0019).

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russia

    V. V. Grigoriev, M. I. Lavrov, V. L. Zamoyski, V. A. Palyulin &  S. O. Bachurin

  2. Faculty of Chemistry, Moscow State University, 119991, Moscow, Russia

    M. I. Lavrov & V. A. Palyulin

  3. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, 125315, Moscow, Russia

    T. L. Garibova

Authors
  1. V. V. Grigoriev
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  2. M. I. Lavrov
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  3. V. L. Zamoyski
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  4. T. L. Garibova
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  5. V. A. Palyulin
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  6. S. O. Bachurin
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Corresponding author

Correspondence to V. L. Zamoyski.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by M. Batrukova

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Grigoriev, V.V., Lavrov, M.I., Zamoyski, V.L. et al. New Positive Allosteric Modulator of AMPA Receptors: in vitro and in vivo Studies. Dokl Biochem Biophys 488, 304–306 (2019). https://doi.org/10.1134/S160767291905003X

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  • DOI: https://doi.org/10.1134/S160767291905003X

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