Perfusion of the pelvic bone marrow is reduced in the postmenopausal group and with age. Quantitative dynamic contrast-enhanced MRI could reflect the blood supply characteristics and hemodynamic changes of the pelvic bone marrow. These results contribute to the description of osteoporosis in the postmenopausal females and the elderly. INTRODUCTION To investigate the effect of menstrual status and age on the perfusion of pelvic bone marrow in adult females using quantitative dynamic contrast-enhanced MRI (DCE-MRI). METHODS In total, 96 adult females who underwent DCE-MRI between September 2017 and December 2017 were included. All the subjects' quantitative DCE-MRI parameters of pelvic bone marrow were measured and retrospectively analyzed, including Ktrans (volume transfer constant), Kep (efflux rate constant), and Ve (interstitial volume). According to their menstrual status, the subjects were divided into a premenopausal group (n = 39) and a postmenopausal group (n = 57), and the two groups were then divided into four subgroups according to age. The intraobserver reliability was assessed by the intraclass correlation coefficient (ICC). The parameters were compared between different menstrual status groups and age subgroups by Mann-Whitney test, and Spearman correlation analysis was used to evaluate the correlation between the age and the quantitative parameters. RESULTS The ICCs of the Ktrans, Kep, and Ve values were 0.989, 0.974, and 0.920, respectively. Ktrans, Kep, and Ve of the premenopausal group were significantly higher than those of the postmenopausal group (P < 0.05). The overall age was negatively correlated with Ktrans, Kep, and Ve (r = - 0.590, - 0.357, and - 0.381, respectively, P < 0.05). In the premenopausal group, Ktrans and Ve were significantly higher in subgroup 1 (≤ 40 years) compared with subgroup 2 (> 40 years) (P < 0.05), and age showed a negative correlation with Ktrans and Ve (r = - 0.344 and - 0.334, respectively, P < 0.05). In the postmenopausal group, Ktrans and Kep were significantly higher in subgroup 3 (≤ 60 years) compared with subgroup 4 (> 60 years) (P < 0.05), and age showed a negative correlation with Ktrans and Kep (r = - 0.460 and - 0.303, respectively, P < 0.05). CONCLUSION Menstrual status and age have significant effects on the perfusion of the pelvic bone marrow microenvironment in adult females and that the microenvironment of the pelvic bone marrow displays different changes at different age stages. Quantitative DCE-MRI has contributed to the interpretation of the pelvic bone marrow perfusion status.

中文翻译：

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成年女性盆腔骨髓动态增强磁共振成像特征及影响因素研究[J].

绝经后组和随着年龄的增长，盆腔骨髓灌注减少。定量动态增强MRI可以反映盆腔骨髓的血供特征和血流动力学变化。这些结果有助于描述绝经后女性和老年人的骨质疏松症。引言 使用定量动态对比增强 MRI (DCE-MRI) 研究月经状况和年龄对成年女性盆腔骨髓灌注的影响。方法 共纳入 2017 年 9 月至 2017 年 12 月期间接受 DCE-MRI 的 96 名成年女性。对所有受试者的盆腔骨髓DCE-MRI定量参数进行测量和回顾性分析，包括Ktrans（体积传递常数）、Kep（流出速率常数）和Ve（间质体积）。根据月经状况，将受试者分为绝经前组（n = 39）和绝经后组（n = 57），然后根据年龄将两组分为四个亚组。通过组内相关系数（ICC）评估观察者内的可靠性。通过Mann-Whitney检验比较不同月经状态组和年龄亚组的参数，并使用Spearman相关分析评估年龄与定量参数之间的相关性。结果Ktrans、Kep和Ve值的ICC分别为0.989、0.974和0.920。绝经前组Ktrans、Kep、Ve显着高于绝经后组（P < 0.05）。总年龄与 Ktrans、Kep 和 Ve 呈负相关（r = - 0.590、- 0.357 和 - 0.381，分别，P < 0.05）。在绝经前组中，亚组 1（≤40 岁）的 Ktrans 和 Ve 显着高于亚组 2（> 40 岁）（P < 0.05），并且年龄与 Ktrans 和 Ve 呈负相关（r = - 0.344 和- 0.334，分别，P < 0.05）。在绝经后组中，亚组 3（≤60 岁）的 Ktrans 和 Kep 显着高于亚组 4（> 60 岁）（P < 0.05），并且年龄与 Ktrans 和 Kep 呈负相关（r = - 0.460 和- 0.303，分别，P < 0.05）。结论 月经状况和年龄对成年女性盆腔骨髓微环境灌注有显着影响，盆腔骨髓微环境在不同年龄阶段呈现不同的变化。