The functions of body gradually decrease as the age increases, leading to a higher frequency of incidence of age-related diseases. Diseases associated with aging in the respiratory system include chronic obstructive pulmonary disease (COPD), IPF (idiopathic pulmonary fibrosis), asthma, lung cancer, and so on. The mitochondrial dysfunction is not only a sign of aging, but also is a disease trigger. This article aims to explain mitochondrial dysfunction as an aging marker, and its role in aging diseases of lung. We also discuss whether the mitochondria can be used as a target for the treatment of aging lung disease.

中文翻译：

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线粒体功能障碍和慢性肺部疾病。

随着年龄的增长，身体的功能逐渐下降，导致与年龄有关的疾病的发病率更高。与呼吸系统衰老相关的疾病包括慢性阻塞性肺疾病（COPD），IPF（特发性肺纤维化），哮喘，肺癌等。线粒体功能障碍不仅是衰老的迹象，而且是疾病的诱因。本文旨在解释线粒体功能障碍作为衰老标记，及其在肺衰老疾病中的作用。我们还讨论了线粒体是否可以用作治疗衰老性肺病的靶标。