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Mitochondrial dysfunction and chronic lung disease

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Abstract

The functions of body gradually decrease as the age increases, leading to a higher frequency of incidence of age-related diseases. Diseases associated with aging in the respiratory system include chronic obstructive pulmonary disease (COPD), IPF (idiopathic pulmonary fibrosis), asthma, lung cancer, and so on. The mitochondrial dysfunction is not only a sign of aging, but also is a disease trigger. This article aims to explain mitochondrial dysfunction as an aging marker, and its role in aging diseases of lung. We also discuss whether the mitochondria can be used as a target for the treatment of aging lung disease.

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Acknowledgments

TT-F, MN-W, XW-W, and HY-X are supported by Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital.TT-F and MN-W are co-first authors.

Funding

This work is supported by the National Key Research and Development Program of China (No. 2016YFA0201402) and the National Natural Science Foundation of China (No. 81602492).

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  1. Tingting Fang and Manni Wang contributed equally to this work and they are co-first authors.

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  1. Lab of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and National Collaborative Innovation Center, Chengdu, 610041, China

    Tingting Fang, Manni Wang, Hengyi Xiao & Xiawei Wei

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Fang, T., Wang, M., Xiao, H. et al. Mitochondrial dysfunction and chronic lung disease. Cell Biol Toxicol 35, 493–502 (2019). https://doi.org/10.1007/s10565-019-09473-9

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