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Glycan structures and their recognition roles in the human blood group ABH/Ii, Lea, b, x, y and Sialyl Lea,x active cyst glycoproteins.
Glycoconjugate Journal ( IF 2.7 ) Pub Date : 2019-11-26 , DOI: 10.1007/s10719-019-09887-x
Albert M. Wu

Human ovarian cyst glycoproteins (HOC, cyst gps) isolated from pseudomucinous type of human ovarian cyst fluids is one of the richest and pioneer sources for studying biosynthesis, structures and functional roles of blood group ABH, Lea,b,x,y, sLea and sLex active glycoproteins. After 70+ years of exploration, four top highlights are shared. (i) an updated concept of glycotopes and their internal structures in cyst gps was composited; (ii) the unknown codes of new genes in secreted cyst gps were unlocked as Lex and Ley; (iii) recognition profiles of cyst glycans and a sialic acid-rich (18%) glycan with lectins and antibodies were shown. (iv) Co-expression of Blood Group A/ A-Leb/y and B/B-Leb/y active Glycotopes in the same glycan chains were isolated and illustrated. These are the most advanced achievements since 1980.

中文翻译:

糖蛋白结构及其在人血ABH / II,Lea,b,x,y和Sialyl Lea,x活性囊肿糖蛋白中的识别作用。

从假粘液型人卵巢囊液中分离出的人卵巢囊肿糖蛋白(HOC,cyst gps)是研究ABHLe a,b,x,ysLe血型的生物合成,结构和功能作用的最丰富的先驱资源之一asLe x活性糖蛋白。经过70 +多年的探索,四大亮点共享。(i)结合了囊肿gps中糖基及其内部结构的更新概念;(ii)分泌的囊肿gps中新基因的未知密码被解锁为Le xLe y; (iii)显示了囊状聚糖和富含唾液酸(18%)的聚糖与凝集素和抗体的识别曲线。(iv)在同一聚糖链中共表达血液A / A-Le b / yB / B-Le b / y活性糖基。这些是自1980年以来最先进的成就。
更新日期:2019-11-26
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