Leukemia cell proliferation requires up-regulation and rewiring of metabolic pathways to feed anabolic cell growth. Oncogenic drivers directly and indirectly regulate metabolic pathways, and aberrant metabolism is central not only for leukemia proliferation and survival, but also mediates oncogene addiction with significant implications for the development of targeted therapies. This review explores leukemia metabolic circuitries feeding anabolism, redox potential, and energy required for tumor propagation with an emphasis on emerging therapeutic opportunities.

中文翻译：

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白血病的代谢依赖性和脆弱性。

白血病细胞增殖需要上调和重新定义代谢途径，以促进合成代谢细胞的生长。致癌驱动因子直接和间接调节代谢途径，异常代谢不仅是白血病增殖和存活的中心，而且还介导致癌基因成瘾，这对靶向治疗的发展具有重要意义。这篇综述探讨了代谢代谢，氧化还原电位和肿瘤扩散所需能量的白血病代谢途径，重点是新兴的治疗机会。