Metabolic dependencies and vulnerabilities in leukemia
- 1Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA;
- 2Department of Pediatrics, Columbia University, New York, NY 10032, USA;
- 3Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
- Corresponding author: af2196{at}columbia.edu
Abstract
Leukemia cell proliferation requires up-regulation and rewiring of metabolic pathways to feed anabolic cell growth. Oncogenic drivers directly and indirectly regulate metabolic pathways, and aberrant metabolism is central not only for leukemia proliferation and survival, but also mediates oncogene addiction with significant implications for the development of targeted therapies. This review explores leukemia metabolic circuitries feeding anabolism, redox potential, and energy required for tumor propagation with an emphasis on emerging therapeutic opportunities.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.326470.119.
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Freely available online through the Genes & Development Open Access option.
This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
