Abstract

Diterpenoid alkaloids have neroprotective activity. Herein, three napelline-type diterpenoid alkaloids 1–3, two aconitine-type diterpenoid alkaloids 4–5, and one isoquinline-type alkaloid 6, as well as one lignan glycoside 7, have been isolated from the roots of Aconitum pendulum Busch. Compounds 1 and 7 were new compounds, and their chemical structures were determined on the basis of nuclear magnetic resonance (NMR) spectra and mass spectrometry analysis. A ThT assay revealed that compound 2 showed significant disaggregation potency on the Aβ₁₋₄₂ aggregates.

Graphical Abstract

中文翻译：

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乌头钟根的二萜类生物碱和一个木质素。

摘要

二萜类生物碱具有神经保护活性。这里，3 napelline型萜生物碱1 - 3，双乌头碱型二萜生物碱4 - 5，和一个isoquinline型生物碱6，以及一个木脂素糖苷7，从根部已分离乌头摆布施。化合物1和7是新化合物，其化学结构是根据核磁共振（NMR）光谱和质谱分析确定的。甲的ThT测定显示化合物2表现出显著分解效力上的A β _1-42 聚集体。

图形概要