People worldwide are living longer, and it is estimated that by 2050, the proportion of the world's population over 60 years of age will nearly double. Natural lung aging is associated with molecular and physiological changes that cause alterations in lung function, diminished pulmonary remodeling and regenerative capacity, and increased susceptibility to acute and chronic lung diseases. As the aging population rapidly grows, it is essential to examine how alterations in cellular function and cell-to-cell interactions of pulmonary resident cells and systemic immune cells contribute to a higher risk of increased susceptibility to infection and development of chronic diseases, such as chronic obstructive pulmonary disease and interstitial pulmonary fibrosis. This review provides an overview of physiological, structural, and cellular changes in the aging lung and immune system that facilitate the development and progression of disease.

中文翻译：

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衰老和肺部疾病。

全球人民的寿命更长，据估计，到2050年，全球60岁以上人口的比例将增加近一倍。天然肺衰老与分子和生理变化有关，这些变化会导致肺功能改变，肺重构和再生能力减弱，以及对急性和慢性肺部疾病的敏感性增加。随着老龄化人口的快速增长，必须检查肺部驻留细胞与全身免疫细胞的细胞功能以及细胞间相互作用的变化如何导致对诸如慢性病等感染和发展的易感性增加的较高风险。慢性阻塞性肺疾病和间质性肺纤维化。这篇评论概述了生理，结构，