Inflammation has a central role in the etiology of type 2 diabetes (T2D) and its complications. Both genetic and epigenetic factors have been implicated in the development of T2D-associated inflammation. Epigenetic mechanisms regulate the function of several components of the immune system. Diabetic conditions trigger aberrant epigenetic alterations that contribute to the progression of insulin resistance and β-cell dysfunction by induction of inflammatory responses. Thus, targeting epigenetic factors and modifications, as one of the underlying causes of inflammation, could lead to the development of novel immune-based strategies for the treatment of T2D. The aim of this review is to provide an overview of the epigenetic mechanisms involved in the propagation and perpetuation of chronic inflammation in T2D. We also discuss the possible anti-inflammatory approaches that target epigenetic factors for the treatment of T2D.

中文翻译：

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表观遗传因素的炎症作用和2型糖尿病的改变。

炎症在2型糖尿病（T2D）及其并发症的病因中起着核心作用。遗传和表观遗传因素均与T2D相关炎症的发展有关。表观遗传机制调节免疫系统某些组成部分的功能。糖尿病会触发异常的表观遗传学改变，通过诱发炎症反应而导致胰岛素抵抗和β细胞功能障碍的发展。因此，靶向表观遗传因素和修饰作为炎症的根本原因之一，可以导致开发基于免疫的新型策略来治疗T2D。这篇综述的目的是概述与T2D中慢性炎症的传播和永存有关的表观遗传机制。