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The inflammatory effect of epigenetic factors and modifications in type 2 diabetes

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Abstract

Inflammation has a central role in the etiology of type 2 diabetes (T2D) and its complications. Both genetic and epigenetic factors have been implicated in the development of T2D-associated inflammation. Epigenetic mechanisms regulate the function of several components of the immune system. Diabetic conditions trigger aberrant epigenetic alterations that contribute to the progression of insulin resistance and β-cell dysfunction by induction of inflammatory responses. Thus, targeting epigenetic factors and modifications, as one of the underlying causes of inflammation, could lead to the development of novel immune-based strategies for the treatment of T2D. The aim of this review is to provide an overview of the epigenetic mechanisms involved in the propagation and perpetuation of chronic inflammation in T2D. We also discuss the possible anti-inflammatory approaches that target epigenetic factors for the treatment of T2D.

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Acknowledgements

This work was supported by the Iran National Science Foundation with the award number 94000647.

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  1. Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran

    Mohamad Akbari & Vahideh Hassan-Zadeh

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Akbari, M., Hassan-Zadeh, V. The inflammatory effect of epigenetic factors and modifications in type 2 diabetes. Inflammopharmacol 28, 345–362 (2020). https://doi.org/10.1007/s10787-019-00663-9

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