Naturally occurring metalloproteins contain metal ions either to introduce a special reactivity or to stabilize a peptide structure. Since the early 1990s, chemists have been trying to use metal coordination for the fixation of short artificial peptides in well-defined cyclic structures. In this tutorial review a survey of the general approaches towards metallacyclopeptides as small cyclic peptide derivatives or as a part of a bigger alpha-helix (or beta-sheet) structure is given. In three case studies it is shown how naturally occurring compounds can be mimicked by metal coordination to non-natural peptide derivatives.

中文翻译：

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金属环肽：天然存在的肽的人工类似物。

天然存在的金属蛋白包含金属离子，以引入特殊的反应性或稳定肽结构。自1990年代初以来，化学家一直在尝试使用金属配位技术将短的人造肽固定在明确的环状结构中。在本教程中，本文概述了金属环肽作为小环肽衍生物或作为较大的α-螺旋（或β-折叠）结构的一部分的一般方法。在三个案例研究中，表明了如何通过金属配位与非天然肽衍生物模拟天然存在的化合物。