Issue 6, 2005
From the journal:

Chemical Society Reviews

Metallacyclopeptides: Artificial analogues of naturally occurring peptides

Markus Albrechta  and  Patrick Stortza  

a Institut für Organische Chemie, RWTH-Aachen, Professor-Pirlet-Strasse 1, D-52074 Aachen, Germany
E-mail: markus.albrecht@oc.rwth-aachen.de

Abstract

Naturally occurring metalloproteins contain metal ions either to introduce a special reactivity or to stabilize a peptide structure. Since the early 1990s, chemists have been trying to use metal coordination for the fixation of short artificial peptides in well-defined cyclic structures. In this tutorial review a survey of the general approaches towards metallacyclopeptides as small cyclic peptide derivatives or as a part of a bigger α-helix (or β-sheet) structure is given. In three case studies it is shown how naturally occurring compounds can be mimicked by metal coordination to non-natural peptide derivatives.

Graphical abstract: Metallacyclopeptides: Artificial analogues of naturally occurring peptides

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Article information

DOI
https://doi.org/10.1039/B405660D
Article type
Tutorial Review
Submitted
01 Feb 2005
First published
01 Mar 2005

Chem. Soc. Rev., 2005,34, 496-506

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Metallacyclopeptides: Artificial analogues of naturally occurring peptides

M. Albrecht and P. Stortz, Chem. Soc. Rev., 2005, 34, 496 DOI: 10.1039/B405660D

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