OBJECTIVE To analyze the lipid and glycemic profiles in relation to age, time elapsed post injury and the level of injury in a group of patients with SCI. SUBJECTS 2135 subjects with SCI were recruited during the annual routine health check-up carried out at the Institut Guttmann of Badalona, in Spain. The patients were classified according to the level of SCI and their age. METHODS Serum lipid profiles and glycemic (glucose) levels were determined. Data was collected between 1996 and 2001, all biochemical analysis being performed by the same laboratory. RESULTS Serum cholesterol levels show a statistically significant correlation with patient's age(P<0.001) and with time elapsed after injury (P<0.05). Differences can be observed between the values obtained from the different injury level groups (F=22.14; P<0.001). LDL-c shows a statistically significant difference between the four different age groups (F=3.51, P<0.05). There is an increase in plasma triglycerides related to the increase in age of the patients without observable differences between the injury level groups. The concentration of serum glucose increases with age (P<0.001) and also with the time elapsed after injury (P<0.05). CONCLUSION There is a direct relationship between various biochemical parameters (total cholesterol, LDL-c and glucose) and the age of the patients, but not with the severity or time of evolution of the spinal cord injury.

中文翻译：

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脊髓损伤后患者血脂谱和血糖水平的长期变化。

目的分析一组SCI患者的血脂和血糖水平与年龄，受伤后经过的时间以及受伤程度的关系。在西班牙Badalona的Guttmann研究所进行的年度例行健康检查期间，招募了2135名患有SCI的受试者。根据SCI水平和年龄对患者进行分类。方法测定血清脂质谱和血糖（葡萄糖）水平。数据收集于1996年至2001年之间，所有生化分析均由同一实验室进行。结果血清胆固醇水平与患者的年龄（P <0.001）和伤后经过的时间（P <0.05）具有统计学意义的相关性。从不同伤害水平组获得的值之间可以观察到差异（F = 22.14； P <0.001）。LDL-c在四个不同年龄组之间显示出统计学上的显着差异（F = 3.51，P <0.05）。血浆甘油三酸酯的增加与患者年龄的增加有关，而伤害水平组之间没有明显的差异。血清葡萄糖的浓度随着年龄的增长而增加（P <0.001），并且随着受伤后的经过时间的增加而增加（P <0.05）。结论各种生化参数（总胆固醇，LDL-c和葡萄糖）与患者年龄之间存在直接关系，但与脊髓损伤的严重程度或演变时间没有直接关系。血浆甘油三酸酯的增加与患者年龄的增加有关，而伤害水平组之间没有明显的差异。血清葡萄糖的浓度随着年龄的增长而增加（P <0.001），并且随着受伤后的经过时间的增加而增加（P <0.05）。结论各种生化参数（总胆固醇，LDL-c和葡萄糖）与患者年龄之间存在直接关系，但与脊髓损伤的严重程度或演变时间没有直接关系。血浆甘油三酸酯的增加与患者年龄的增加有关，而伤害水平组之间没有明显的差异。血清葡萄糖的浓度随着年龄的增长而增加（P <0.001），并且随着受伤后的经过时间的增加而增加（P <0.05）。结论各种生化参数（总胆固醇，LDL-c和葡萄糖）与患者年龄之间存在直接关系，但与脊髓损伤的严重程度或演变时间没有直接关系。