OBJECTIVE To investigate the effect of antioxidant supplementation on viral load and the antioxidant/reactive oxygen species system in people with HIV. DESIGN Single centre, prospective, dose comparison study. SETTING Outpatient clinic specializing in HIV care. SUBJECTS Sixty-six participants were sequentially recruited by advertisement, and 48 subjects completed the study. INTERVENTIONS A recommended dose antioxidant regimen (5,450 IU vitamin A as beta-carotene, 250 mg vitamin C, 100 IU vitamin E, 100 microg selenium, 50 mg coenzyme Q10) or a high-dose antioxidant regimen (21,800 IU vitamin A as beta-carotene, 1,000 mg vitamin C, 400 IU vitamin E, 200 microg selenium, 200 mg coenzyme Q10) for a 12 week period. RESULTS Using repeated measures analysis of variance, the changes over treatment time were significant for selenium, glutathione, glutathione peroxidase and lipid peroxides (P < 0.03). Changes in allantoin, uric acid and viral load were not significant (P > 0.05). The main effects for group and the interaction effects were not significant for any of the parameters measured (P > or = 0.05). CONCLUSION Antioxidant supplementation significantly improved some measures of oxidative defence. There was no benefit in using a high-dose supplement in this study.

中文翻译：

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使用抗氧化剂方案进行的初步开放标签剂量比较，以确定对HIV / AIDS男性的病毒载量和氧化应激的影响。

目的探讨抗氧化剂补充剂对HIV感染者病毒载量和抗氧化/活性氧系统的影响。设计单中心，前瞻性，剂量比较研究。设置专门从事艾滋病毒护理的门诊诊所。受试者通过广告招募了66名参与者，有48名受试者完成了研究。干预措施建议剂量的抗氧化剂方案（5,450 IU维生素A作为β-胡萝卜素，250 mg维生素C，100 IU维生素E，100微克硒，50 mg辅酶Q10）或大剂量抗氧化剂方案（21,800 IU维生素A作为β-胡萝卜素，胡萝卜素，1,000毫克维生素C，400 IU维生素E，200微克硒，200毫克辅酶Q10），为期12周。结果使用重复测量方差分析，硒，谷胱甘肽，谷胱甘肽过氧化物酶和脂质过氧化物（P <0.03）。尿囊素，尿酸和病毒载量的变化不显着（P> 0.05）。对于任何测量参数，组的主要影响和相互作用影响均不显着（P>或= 0.05）。结论补充抗氧化剂可以显着改善一些氧化防御措施。在这项研究中使用大剂量补充剂没有益处。