Abstract
Objective: To investigate the effect of antioxidant supplementation on viral load and the antioxidant/reactive oxygen species system in people with HIV.
Design: Single centre, prospective, dose comparison study.
Setting: Outpatient clinic specializing in HIV care.
Subjects: Sixty-six participants were sequentially recruited by advertisement, and 48 subjects completed the study.
Interventions: A recommended dose antioxidant regimen (5450 IU vitamin A as β-carotene, 250 mg vitamin C, 100 IU vitamin E, 100 µg selenium, 50 mg coenzyme Q10) or a high-dose antioxidant regimen (21 800 IU vitamin A as β-carotene, 1000 mg vitamin C, 400 IU vitamin E, 200 µg selenium, 200 mg coenzyme Q10) for a 12 week period.
Results: Using repeated measures analysis of variance, the changes over treatment time were significant for selenium, glutathione, glutathione peroxidase and lipid peroxides (P<0.03). Changes in allantoin, uric acid and viral load were not significant (P>0.05). The main effects for group and the interaction effects were not significant for any of the parameters measured (P≥0.05).
Conclusion: Antioxidant supplementation significantly improved some measures of oxidative defence. There was no benefit in using a high-dose supplement in this study.
Sponsorship: Blackmores Ltd supplied the antioxidant supplements.
European Journal of Clinical Nutrition (2001) 55, 107–114
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Contributions
Guarantor: Marijka Batterham.
Contributors: MB designed the study, was responsible for ethics approval and therapeutic goods administration approval, collected the data, analysed the data, and drafted the paper. JG conceptualized the study and assisted with study design, reviewed the paper. DN designed the serum antioxidant/oxidative stress studies, assisted with the study design, and reviewed the paper. OL conducted the serum antioxidant/oxidative stress assays, assisted with the study design and reviewed the paper. SS assisted with the organization of the study and the data collection, and reviewed the paper. SB organized the dispensing of the supplements and collected the compliance data, assisted with study design and reviewed the paper.
ME was responsible for serum collection and transport of serum to the laboratory, assisted with the organization of the data collection and reviewed the paper. CO assisted with study conceptualization and design and reviewed the paper.
Corresponding author
Rights and permissions
About this article
Cite this article
Batterham, M., Gold, J., Naidoo, D. et al. A preliminary open label dose comparison using an antioxidant regimen to determine the effect on viral load and oxidative stress in men with HIV/AIDS. Eur J Clin Nutr 55, 107–114 (2001). https://doi.org/10.1038/sj.ejcn.1601124
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ejcn.1601124
Keywords
This article is cited by
-
Effect of Human Immunodeficiency Virus on Trace Elements in the Brain
Biological Trace Element Research (2021)
-
Do countries rely on the World Health Organization for translating research findings into clinical guidelines? A case study
Globalization and Health (2016)
-
The effect of standard dose multivitamin supplementation on disease progression in HIV-infected adults initiating HAART: a randomized double blind placebo-controlled trial in Uganda
BMC Infectious Diseases (2015)
-
Multivitamin supplementation in HIV infected adults initiating antiretroviral therapy in Uganda: the protocol for a randomized double blinded placebo controlled efficacy trial
BMC Infectious Diseases (2012)
-
Lymphocyte proliferation and apoptosis in HIV-seropositive and healthy subjects during long-term ingestion of fruit juices or a fruit-vegetable-concentrate rich in polyphenols and antioxidant vitamins
European Journal of Clinical Nutrition (2004)
