Intracellular compartment drug delivery is a promising strategy for the treatment of diseases. By this way, medicines can delivered to particular intracellular compartments. This maximizes the therapeutic efficacy and safety of medicines, particularly of anticancer and antiviral drugs. Intracellular compartment drug delivery is either indirectly by targeting of cell nucleus as central compartment of the cell or directly through the targeting of compartments itself. Drugs or nanoshuttles labeled with compartment's localization signal represent a smart tactic for subcellular compartment targeting. There are several boundaries prevent the arrival of shuttles to the specified intracellular compartments. These boundaries include selective permeability of biomembranes, efflux transporters, and lysosomes. The utilization of specific ligands during design of drug delivery nanoshuttles permits the targeting of specified intracellular compartment. Therefore drugs targeting could correct the diseases associated organelles. This review highlights the direct targeting of the medicines into subcellular compartment as a promising therapeutic strategy.

中文翻译：

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直接将药物靶向细胞内区：问题，局限性和未来展望。

细胞内区隔药物递送是治疗疾病的有前途的策略。通过这种方式，药物可以递送到特定的细胞内区室。这使药物，尤其是抗癌和抗病毒药物的治疗功效和安全性最大化。细胞内区隔药物递送是通过靶向细胞核作为细胞的中央区室而间接地进行，或者直接通过靶向区室本身来进行。标有隔室定位信号的药物或纳米梭代表了针对亚细胞隔室靶向的明智策略。有几个边界阻止穿梭到达指定的细胞内区室。这些边界包括生物膜，外排转运蛋白和溶酶体的选择性渗透性。在药物递送纳米梭的设计过程中特定配体的利用允许靶向特定的细胞内区室。因此，靶向药物可以纠正与细胞器有关的疾病。这篇综述强调了将药物直接靶向亚细胞区室作为一种有前途的治疗策略。