Biological membranes display a staggering complexity of lipids and proteins orchestrating cellular functions. Superior analytical tools coupled with numerous functional cellular screens have enabled us to query their role in cellular signalling, trafficking, guiding protein structure and function-all of which rely on the dynamic membrane lipid properties indispensable for proper cellular functions. Alteration of these has led to emergence of various pathological conditions, thus opening an area of lipid-centric therapeutic approaches. This perspective is a short summary of the dynamic properties of membranes essential for proper cellular functions, dictating both protein and lipid functions, and mis-regulated in diseases. Towards the end, we focus on some challenges lying ahead and potential means to tackle the same, mainly underscored by multi-disciplinary approaches.

中文翻译：

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健康与疾病中的膜动力学：对细胞信号传导的影响。

生物膜显示出协调细胞功能的脂质和蛋白质的复杂性。出色的分析工具，加上众多功能性细胞筛选，使我们能够查询它们在细胞信号传导，运输，指导蛋白质结构和功能中的作用，所有这些都依赖于正常细胞功能必不可少的动态膜脂特性。这些改变导致各种病理状况的出现，从而开辟了以脂质为中心的治疗方法领域。该观点简要概述了膜的动态特性，这些膜对于适当的细胞功能，决定蛋白质和脂质的功能以及在疾病中的调节失调至关重要。最后，我们着眼于一些挑战以及解决这些挑战的潜在方法，