STING is a newly identified adaptor protein for sensing cytosolic nucleic acid. It is well established that STING plays a crucial role in innate immune response via inducing production of type I IFN. Emerging evidence suggests that the activation of STING-dependent signaling is also implicated in the process of cell death, such as apoptosis, pyroptosis, necroptosis, and autophagy. Of note, the pro-death outcome is even predominant in certain cell types, like lymphocytes, myeloid cells, and hepatocytes. Given that STING agonists are being tested for enhancing antitumor immune responses, it is necessary to fully understand the outcome of STING activation. The anti-microorganism response mediated by STING has been well described; therefore, we focus on the role of STING-dependent signaling on cell death in this review.

中文翻译：

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STING依赖信号转导对细胞死亡的新兴作用。

STING是新近鉴定出的用于感知胞质核酸的衔接子蛋白。公认的是，STING通过诱导I型IFN的产生在先天免疫应答中起关键作用。越来越多的证据表明，依赖STING的信号传导也与细胞死亡过程有关，例如细胞凋亡，凋亡，坏死性坏死和自噬。值得注意的是，促死结局甚至在某些细胞类型（如淋巴细胞，骨髓细胞和肝细胞）中占主导地位。鉴于正在测试STING激动剂可增强抗肿瘤免疫反应，因此有必要充分了解STING激活的结果。已经很好地描述了由STING介导的抗微生物反应。因此，在本综述中，我们重点研究STING依赖性信号传导对细胞死亡的作用。