Abstract

The results of the study of the effect of a mononuclear dinitrosyl iron complex (DNIC7) with functional sulfur-containing ligands (NO donors) on the viability of multiple myeloma cells are presented. It was shown that DNIC7 decreased cell viability and inhibited the proliferation of multiple myeloma cells, i.e., exhibits cytotoxic properties. Fluorescent analysis showed that the DNIC7 compound decreases the level of intracellular glutathione and increases the level of reactive oxygen species in multiple myeloma cells. It is assumed that DNIC7 has a therapeutic potential for the treatment of cancer.

中文翻译：

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二亚硝基铁络合物（NO供体）对多发性骨髓瘤细胞的抗癌活性。

摘要

提出了具有功能性含硫配体（NO供体）的单核二亚硝基铁络合物（DNIC7）对多发性骨髓瘤细胞生存力的影响的研究结果。结果表明，DNIC7降低细胞活力并抑制多发性骨髓瘤细胞的增殖，即表现出细胞毒性。荧光分析表明，DNIC7化合物降低了多发性骨髓瘤细胞中细胞内谷胱甘肽的水平，并增加了活性氧的水平。假定DNIC7具有用于治疗癌症的治疗潜力。