Abstract
The results of the study of the effect of a mononuclear dinitrosyl iron complex (DNIC7) with functional sulfur-containing ligands (NO donors) on the viability of multiple myeloma cells are presented. It was shown that DNIC7 decreased cell viability and inhibited the proliferation of multiple myeloma cells, i.e., exhibits cytotoxic properties. Fluorescent analysis showed that the DNIC7 compound decreases the level of intracellular glutathione and increases the level of reactive oxygen species in multiple myeloma cells. It is assumed that DNIC7 has a therapeutic potential for the treatment of cancer.
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ACKNOWLEDGMENTS
Experiments were performed using the equipment of the Medical Chemistry Center of the Institute of Problems of Chemical Physics, Russian Academy of Sciences (Chernogolovka).
Funding
The study was supported by the Basic Research Program no. 1.42 P “Basic Research for Biomedical Technologies” and the State Assignment (registration no. 0089-2019-0014).
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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.
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Translated by M. Batrukova
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Akentieva, N.P., Sanina, N.A., Prichodchenko, T.R. et al. Anticancer Activity of Dinitrosyl Iron Complex (NO Donor) on the Multiple Myeloma Cells. Dokl Biochem Biophys 486, 238–242 (2019). https://doi.org/10.1134/S1607672919030190
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DOI: https://doi.org/10.1134/S1607672919030190