Abstract

Infection of mice with influenza A viruses led to the formation of clones of lymphocytes that specifically recognizes viral domains in the central zone of the NSP protein (amino acid positions 83–119). Computer analysis of the primary structure of the NSP protein showed the presence of T-cell epitopes in the central part of the NSP molecule. The findings indicate that the viral NSP gene is expressed in the infected animals and verify the concept of the bipolar strategy (ambisense strategy) of the influenza A virus genome.

中文翻译：

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甲型流感病毒的阴性NS RNA链中编码的NSP蛋白可在感染动物中诱导细胞免疫反应。

摘要

小鼠感染甲型流感病毒会导致淋巴细胞克隆的形成，该克隆特异性识别NSP蛋白中央区域的病毒域（氨基酸位置83–119）。NSP蛋白一级结构的计算机分析表明，NSP分子中心部分存在T细胞表位。这些发现表明病毒NSP基因在受感染的动物中表达，并证实了甲型流感病毒基因组的双极策略（歧义策略）的概念。