Abstract

In the present study, we analyzed the uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from the dorsal striatum of mice with constitutive inactivation of all three synuclein-coding genes and wild-type mice. Synuclein deficiency substantially compromised the uptake of this neurotransmitter by synaptic vesicles but had no effect on synaptosomal dopamine uptake.

中文翻译：

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突触核蛋白缺乏会降低突触小泡摄取多巴胺的效率。

摘要

在本研究中，我们分析了完整的突触小体和从小鼠背侧纹状体分离的纯化突触小泡对放射性标记的多巴胺的摄取，而这三种突触核蛋白编码基因和野生型小鼠均组成性失活。突触核蛋白缺乏严重损害了突触小泡对该神经递质的摄取，但对突触体多巴胺摄取没有影响。