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Synuclein Deficiency Decreases the Efficiency of Dopamine Uptake by Synaptic Vesicles

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

In the present study, we analyzed the uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from the dorsal striatum of mice with constitutive inactivation of all three synuclein-coding genes and wild-type mice. Synuclein deficiency substantially compromised the uptake of this neurotransmitter by synaptic vesicles but had no effect on synaptosomal dopamine uptake.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Moscow oblast, Russia

    N. N. Ninkina, T. V. Tarasova, K. D. Chaprov, V. V. Goloborshcheva,  S. O. Bachurin & V. L. Buchman

  2. Cardiff University, School of Biosciences, Sir Martin Evans Building, Museum Avenue, CF10 3AX, Cardiff, United Kingdom

    N. N. Ninkina, T. V. Tarasova & V. L. Buchman

Authors
  1. N. N. Ninkina
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  2. T. V. Tarasova
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  3. K. D. Chaprov
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  4. V. V. Goloborshcheva
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  5. S. O. Bachurin
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  6. V. L. Buchman
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Correspondence to K. D. Chaprov.

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Translated by M. Batrukova

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Ninkina, N.N., Tarasova, T.V., Chaprov, K.D. et al. Synuclein Deficiency Decreases the Efficiency of Dopamine Uptake by Synaptic Vesicles. Dokl Biochem Biophys 486, 168–170 (2019). https://doi.org/10.1134/S1607672919030025

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  • DOI: https://doi.org/10.1134/S1607672919030025

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