The Saccharomyces cerevisiae cell wall integrity (CWI) pathway took this name when its role in the cell response to cell wall aggressions was clearly established. The receptors involved in sensing the damage, the relevant components operating in signaling to the MAPK Slt2, the transcription factors activated by this MAPK, as well as some key regulatory mechanisms have been identified and characterized along almost 30 years. However, other stimuli that do not alter specifically the yeast cell wall, including protein unfolding, low or high pH, or plasma membrane, oxidative and genotoxic stresses, have been also found to trigger the activation of this pathway. In this review, we compile almost forty non-cell wall-specific compounds or conditions, such as tunicamycin, hypo-osmotic shock, diamide, hydroxyurea, arsenate, and rapamycin, which induce these stresses. Relevant aspects of the CWI-mediated signaling in the response to these non-conventional pathway activators are discussed. The data presented here highlight the central and key position of the CWI pathway in the safeguard of yeast cells to a wide variety of external aggressions.

中文翻译：

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不仅是墙壁：打开酵母CWI途径的其他方法。

在酿酒酵母当细胞壁完整性（CWI）通路在细胞对细胞壁侵袭的反应中的作用得到明确确立时，就以该名字命名。在将近30年的时间里，已经确定并鉴定了与感知损伤有关的受体，向MAPK Slt2发出信号的相关成分，由该MAPK激活的转录因子以及一些关键的调控机制。然而，还发现其他未具体改变酵母细胞壁的刺激，包括蛋白质解折叠，低pH或高pH或质膜，氧化和遗传毒性应激，均可触发该途径的激活。在这篇综述中，我们汇编了近四十种非细胞壁特异性化合物或条件，例如衣霉素，低渗休克，二酰胺，羟基脲，砷酸盐和雷帕霉素，它们会引起这些压力。讨论了对这些非常规途径激活剂的反应中CWI介导的信号传导的相关方面。此处提供的数据突出了CWI途径在酵母细胞对各种外部攻击的保护中的中心和关键位置。