Abstract
The Saccharomyces cerevisiae cell wall integrity (CWI) pathway took this name when its role in the cell response to cell wall aggressions was clearly established. The receptors involved in sensing the damage, the relevant components operating in signaling to the MAPK Slt2, the transcription factors activated by this MAPK, as well as some key regulatory mechanisms have been identified and characterized along almost 30 years. However, other stimuli that do not alter specifically the yeast cell wall, including protein unfolding, low or high pH, or plasma membrane, oxidative and genotoxic stresses, have been also found to trigger the activation of this pathway. In this review, we compile almost forty non-cell wall-specific compounds or conditions, such as tunicamycin, hypo-osmotic shock, diamide, hydroxyurea, arsenate, and rapamycin, which induce these stresses. Relevant aspects of the CWI-mediated signaling in the response to these non-conventional pathway activators are discussed. The data presented here highlight the central and key position of the CWI pathway in the safeguard of yeast cells to a wide variety of external aggressions.
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This research was funded by grants BIO2016-75030-P (Ministerio de Economía y Competitividad), and S2017/BMD-3691-InGEMICS-CM (Comunidad de Madrid and European Structural and Investment Funds). E.J-G was supported by a predoctoral contract from the Universidad Complutense de Madrid, E.A-C by a contract from the Community of Madrid and co-financed by the European Social Fund within the Youth Employment Operative Program and the Youth Employment Initiative (YEI), and A.S-M by a predoctoral contract from the Ministerio de Ciencia, Innovación y Universidades of Spain.
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Jiménez-Gutiérrez, E., Alegría-Carrasco, E., Sellers-Moya, Á. et al. Not just the wall: the other ways to turn the yeast CWI pathway on. Int Microbiol 23, 107–119 (2020). https://doi.org/10.1007/s10123-019-00092-2
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DOI: https://doi.org/10.1007/s10123-019-00092-2