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The peculiar genetics of the ribosomal DNA blurs the boundaries of transgenerational epigenetic inheritance.
Chromosome Research ( IF 2.4 ) Pub Date : 2018-12-04 , DOI: 10.1007/s10577-018-9591-2
Farah Bughio 1, 2 , Keith A Maggert 1, 2
Affiliation  

Our goal is to draw a line-hypothetical in its totality but experimentally supported at each individual step-connecting the ribosomal DNA and the phenomenon of transgenerational epigenetic inheritance of induced phenotypes. The reasonableness of this hypothesis is offset by its implication, that many (or most) (or all) of the cases of induced-and-inherited phenotypes that are seen to persist for generations are instead unmapped induced polymorphisms in the ribosomal DNA, and thus are the consequence of the peculiar and enduringly fascinating genetics of the highly transcribed repeat DNA structure at that locus.

中文翻译:

核糖体DNA的特殊遗传学模糊了跨代表观遗传遗传的边界。

我们的目标是在总体上以假想的方式画一条线,但在连接核糖体DNA和诱导表​​型的跨代表观遗传遗传现象的每个单独步骤上均提供实验支持。该假设的合理性被其含义所抵消,认为许多世代持续存在的诱导和遗传表型的许多(或大多数)(或所有)病例在核糖体DNA中是未映射的诱导多态性,因此是该位点高度转录的重复DNA结构独特而持久的遗传学的结果。
更新日期:2019-11-01
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