WF14861, 3-(N-(1-(N-(4-aminobutyl)-N-(3-aminopropyl)carbamoyl)-2-(4-hydroxyphenyl )ethyl)carbamoyl)oxirane-2-carboxylic acid, was obtained from the culture mycelium of Colletotrichum sp. as a novel cathepsins B and L inhibitor. WF14861 also showed inhibitory activities against bone derived crude protease and other cysteine proteases in vitro. The compound ameliorated the tissue damage and the bone destruction models of low-calcium-diet-fed mouse and adjuvant arthritis rat model.

中文翻译：

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WF14861，Colletotrichum sp。生产的新型组织蛋白酶B和L抑制剂。二。生物学特性。

WF14861，由以下物质获得3-（N-（1-（N-（4-氨基丁基）-N-（3-氨基丙基）氨基甲酰基）-2-（4-羟基苯基）乙基）氨基甲酰基）环氧乙烷-2-羧酸。炭疽菌的菌丝体。作为新型组织蛋白酶B和L抑制剂。WF14861还显示出对骨衍生的粗蛋白酶和其他半胱氨酸蛋白酶的体外抑制活性。该化合物改善了低钙饮食喂养小鼠和佐剂关节炎大鼠模型的组织损伤和骨破坏模型。