WF14861, a New Cathepsins B and L Inhibitor Produced by Colletotrichum sp. II. Biological Properties

TAKANAO OTSUKA; YUKO MURAMATSU; KAZUAKI NIIKURA; MASANORI OKAMOTO; MOTOHIRO HINO; SEIJI HASHIMOTO

doi:10.7164/antibiotics.52.542

WF14861, a New Cathepsins B and L Inhibitor Produced by Colletotrichum sp.

II. Biological Properties

TAKANAO OTSUKA, YUKO MURAMATSU, KAZUAKI NIIKURA, MASANORI OKAMOTO, MOTOHIRO HINO, SEIJI HASHIMOTO

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JOURNAL FREE ACCESS

1999 Volume 52 Issue 6 Pages 542-547

DOI https://doi.org/10.7164/antibiotics.52.542

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Abstract

WF14861, 3-(N-(1-(N-(4-aminobutyl)-N-(3-aminopropyl)carbamoyl)-2-(4-hydroxyphenyl)ethyl)carbamoyl)oxirane-2-carboxylic acid, was obtained from the culture mycelium of Colletotrichum sp. as a novel cathepsins B and L inhibitor. WF14861 also showed inhibitory activities against bone derived crude protease and other cysteine proteases in vitro. The compound ameliorated the tissue damage and the bone destruction models of low-calcium-diet-fed mouse and adjuvant arthritis rat model.

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