Seaweeds of the genera Laminaria, Gelidium, and Porphyra have been used in both food and non-food industries due to their unique properties and characteristic biological activity. This study assesses the antioxidant activity and immunomodulatory properties of the acidic polysaccharides extracted from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum collected in the Atlantic coast of Tarifa (Cadiz, Spain). The proliferation of murine cell line RAW 264 decreased with increasing concentration of polysaccharides of the three algal species. The highest both antioxidant (25.69 μmol TE g⁻¹ DW) and immunomodulatory activities were observed in the sulfated polysaccharides of L. ochroleuca compared to that of P. umbilicalis and G. corneum. Sulfated polysaccharides of L. ochroleuca presented high potential anticancer activity in cell lines of human colon cancer HTC-116 (IC₅₀ = 0.44 mg mL⁻¹), human malignant melanoma G-361 (IC₅₀ = 5.42 mg mL⁻¹), breast adenocarcinoma human MCF-7 (IC₅₀ = 8.32 mg mL⁻¹), and human leukemia U-937 (IC₅₀ = 3.72 mg mL⁻¹). It is concluded that metabolites of L. ochroleuca can offer significant advantages for the pharmaceutical industry, particularly when macrophage activation is required.

中文翻译：

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海带、脐紫菜和石花菜硫酸化多糖的免疫调节和抗氧化活性。


海带属、石花菜属和紫菜属的海藻由于其独特的性质和特有的生物活性而被用于食品和非食品工业。本研究评估了从塔里法（西班牙加的斯）大西洋海岸采集的海带、脐紫菜和石花菜中提取的酸性多糖的抗氧化活性和免疫调节特性。小鼠细胞系 RAW 264 的增殖随着三种藻类多糖浓度的增加而降低。与P. umbilicalis和G. corneum相比，在L. ochroleuca的硫酸化多糖中观察到最高的抗氧化剂（25.69 μmol TE g ^-1 DW）和免疫调节活性。 L. ochroleuca硫酸化多糖在人结肠癌 HTC-116 (IC ₅₀ = 0.44 mg mL ^-1 )、人恶性黑色素瘤 G-361 (IC ₅₀ = 5.42 mg mL ^-1 )、乳腺癌细胞系中表现出较高的潜在抗癌活性腺癌人MCF-7（IC ₅₀ = 8.32 mg mL ^-1 ）和人白血病U-937（IC ₅₀ = 3.72 mg mL ^-1 ）。结论是， L. ochroleuca的代谢物可以为制药工业提供显着的优势，特别是当需要激活巨噬细胞时。