Polymeric nanoparticles have tremendous potential to improve the efficacy of therapeutic cancer treatments by facilitating targeted delivery to a desired site. The physical and chemical properties of polymers can be tuned to accomplish delivery across the multiple biological barriers required to reach diverse subsets of cells. The use of biodegradable polymers as nanocarriers is especially attractive, as these materials can be designed to break down in physiological conditions and engineered to exhibit triggered functionality when at a particular location or activated by an external source. We present how biodegradable polymers can be engineered as drug delivery systems to target the tumor microenvironment in multiple ways. These nanomedicines can target cancer cells directly, the blood vessels that supply the nutrients and oxygen that support tumor growth, and immune cells to promote anticancer immunotherapy.

中文翻译：

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用于治疗癌症的可生物降解聚合物纳米颗粒。


聚合物纳米颗粒具有巨大的潜力，可以通过促进靶向递送至所需部位来提高癌症治疗的功效。可以调整聚合物的物理和化学性质，以实现跨越到达不同细胞亚群所需的多个生物屏障的递送。使用可生物降解的聚合物作为纳米载体特别有吸引力，因为这些材料可以设计为在生理条件下分解，并设计为在特定位置或被外部源激活时表现出触发功能。我们展示了如何将可生物降解的聚合物设计为药物输送系统，以多种方式靶向肿瘤微环境。这些纳米药物可以直接靶向癌细胞、提供支持肿瘤生长的营养和氧气的血管以及促进抗癌免疫治疗的免疫细胞。