Molecular research has vastly advanced our understanding of the mechanism of cancer growth and spread. Targeted approaches utilizing molecular science have yielded provocative results in the treatment of cancer. Oncolytic viruses genetically programmed to replicate within cancer cells and directly induce toxic effect via cell lysis or apoptosis are currently being explored in the clinic. Safety has been confirmed and despite variable efficacy results several dramatic responses have been observed with some oncolytic viruses. This review summarizes results of clinical trials with oncolytic viruses in cancer.

中文翻译：

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溶瘤病毒疗法。

分子研究极大地增进了我们对癌症生长和扩散机制的理解。利用分子科学的靶向方法已在癌症治疗中产生了令人鼓舞的结果。目前正在临床上探索通过基因编程可在癌细胞内复制并通过细胞裂解或凋亡直接诱导毒性作用的溶瘤病毒。安全性已得到证实，尽管疗效结果不一，但对于某些溶瘤病毒仍观察到了许多惊人的反应。这篇综述总结了溶瘤病毒治疗癌症的临床试验结果。