Nematode cys-loop ligand gated ion channels (CLGIC) mediate neurotransmission and are important targets for anthelmintics in parasitic nematodes. The CLGIC superfamily in nematodes includes ion channels gated by acetylcholine, gamma-amino butyric acid (GABA), glutamate, glycine and 5-HT. The macrocyclic lactones and the nicotinic agonists are important groups of anthelmintics that target the glutamate gated chloride channels and the nicotinic acetylcholine receptors, respectively. The model organism Caenorhabditis elegans has the most diverse families of cys-loop LGIC known in any organism. Many parasitic nematodes have homologues of C. elegans receptors but to date no genome wide investigations have been done. The genome sequencing projects of Brugia malayi (clade III) and Trichinella spiralis (clade I) have allowed us to characterise the CLGIC families in these species. Although the main groups of CLGICs targeted by anthelmintics are represented in both the nematode genomes investigated here, the CLGIC family is much smaller in B. malayi and T. spiralis, suggesting that care must be taken when using C. elegans as a model organism for distantly related nematodes.

中文翻译：

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马来丝虫和旋毛虫的 cys-loop 配体门控离子通道基因家族：与秀丽隐杆线虫的比较。

线虫 cys 环配体门控离子通道 (CLGIC) 介导神经传递，是寄生线虫驱虫药的重要靶点。线虫中的 CLGIC 超家族包括由乙酰胆碱、γ-氨基丁酸 (GABA)、谷氨酸、甘氨酸和 5-HT 门控的离子通道。大环内酯和烟碱激动剂是重要的驱虫剂组，它们分别针对谷氨酸门控氯离子通道和烟碱乙酰胆碱受体。模式生物秀丽隐杆线虫具有在任何生物中已知的最多样化的 cys-loop LGIC 家族。许多寄生线虫具有秀丽隐杆线虫受体的同源物，但迄今为止尚未进行全基因组研究。马来亚种（进化枝 III）和旋毛虫（进化枝 I）的基因组测序项目使我们能够表征这些物种中的 CLGIC 家族。尽管这里研究的两个线虫基因组中都代表了驱虫药靶向的主要 CLGIC 家族，但 CLGIC 家族在 B. malayi 和 T. spinis 中要小得多，这表明在使用秀丽隐杆线虫作为模型生物时必须小心远亲线虫。