During the last decades, the prevalence of obesity has increased rapidly among young people. A polymorphism in the promoter region of the IL6 gene (-174G/C), has been previously reported to be involved in obesity and metabolic syndrome development. Therefore, the aim of the study was to examine whether the IL6-174G/C polymorphism influence the association of body fat with low-grade inflammatory markers and blood lipids and lipoproteins in Spanish adolescents. 504 Spanish adolescents participating in the AVENA study were genotyped for the-174G/C polymorphism of the IL6 gene. Anthropometric and body composition measurements were taken and blood samples were collected for plasma molecules determinations. No differences between genotypes were observed in anthropometric values, body composition measurements and plasma markers concentration. Physical activity level differ between genotypes with subjects carrying the C allele of the polymorphism being significantly (p<0.05) more active than GG subjects. The association between body fat mass and plasma glucose was influenced by the -174G/C polymorphism of the IL6 gene. Subjects carrying the C allele of the mutation seem to have higher values of lipoprotein (a) and C-reactive protein as their percentage of body fat mass increase. Our results suggest that this promoter polymorphism influences the association between adiposity and some plasma markers.

中文翻译：

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Il6 基因启动子多态性 (-174G/C) 影响脂肪量与心血管危险因素之间的关联。

在过去的几十年中，肥胖症在年轻人中的流行率迅速增加。IL6 基因 (-174G/C) 启动子区域的多态性先前已报道与肥胖和代谢综合征的发展有关。因此，本研究的目的是检查 IL6-174G/C 多态性是否影响西班牙青少年体内脂肪与低度炎症标志物以及血脂和脂蛋白的关联。参与 AVENA 研究的 504 名西班牙青少年对 IL6 基因的-174G/C 多态性进行了基因分型。进行人体测量和身体成分测量，并收集血液样本用于血浆分子测定。在人体测量值、身体成分测量值和血浆标志物浓度方面没有观察到基因型之间的差异。身体活动水平在基因型之间不同，携带多态性 C 等位基因的受试者比 GG 受试者显着（p<0.05）更活跃。体脂肪量和血浆葡萄糖之间的关联受 IL6 基因的 -174G/C 多态性影响。携带 C 等位基因突变的受试者似乎具有更高的脂蛋白 (a) 和 C 反应蛋白值，因为他们的体脂百分比增加。我们的结果表明，这种启动子多态性影响肥胖和一些血浆标志物之间的关联。携带 C 等位基因突变的受试者似乎具有更高的脂蛋白 (a) 和 C 反应蛋白值，因为他们的体脂百分比增加。我们的结果表明，这种启动子多态性影响肥胖和一些血浆标志物之间的关联。携带 C 等位基因突变的受试者似乎具有更高的脂蛋白 (a) 和 C 反应蛋白值，因为他们的体脂百分比增加。我们的结果表明，这种启动子多态性影响肥胖和一些血浆标志物之间的关联。