The mitochondrial ADP/ATP carrier plays a central role in aerobic cell energetics by providing to the cytosol the ATP generated by oxidative phosphorylation. Though discovered around 40 years ago owing to the existence of unique inhibitors and in spite of numerous experimental approaches, this carrier, which stands as a model of the mitochondrial solute carriers keeps some long-standing mystery. There are still open challenging questions among them the precise ADP/ATP transport mechanism, the functional oligomeric state of the carrier and relationships between human ADP/ATP carrier dysfunctioning and pathologies. Deciphering the 3D structure of this carrier afforded a considerable progress of the knowledge but requires now additional data focused on molecular dynamics from this static picture. State of the art in this topic is reviewed and debated in this paper in view of better comprehending origin of the discrepancies in these questions and, finally, the multiple physiological roles of this carrier in eukaryotic cell economy.

中文翻译：

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线粒体 ADP/ATP 载体：阐明病理生理方面的功能和结构研究。

线粒体 ADP/ATP 载体通过向细胞质提供由氧化磷酸化产生的 ATP，在需氧细胞能量学中起核心作用。尽管由于独特的抑制剂的存在而在大约 40 年前被发现，并且尽管有许多实验方法，但这种作为线粒体溶质载体模型的载体仍然存在一些长期的谜团。其中仍然存在未解决的具有挑战性的问题，即精确的 ADP/ATP 转运机制、载体的功能性寡聚状态以及人类 ADP/ATP 载体功能障碍与病理之间的关系。破译这种载体的 3D 结构为知识提供了相当大的进步，但现在需要额外的数据集中在这张静态图片中的分子动力学上。