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The mitochondrial ADP/ATP carrier: functional and structural studies in the route of elucidating pathophysiological aspects

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Abstract

The mitochondrial ADP/ATP carrier plays a central role in aerobic cell energetics by providing to the cytosol the ATP generated by oxidative phosphorylation. Though discovered around 40 years ago owing to the existence of unique inhibitors and in spite of numerous experimental approaches, this carrier, which stands as a model of the mitochondrial solute carriers keeps some long-standing mystery. There are still open challenging questions among them the precise ADP/ATP transport mechanism, the functional oligomeric state of the carrier and relationships between human ADP/ATP carrier dysfunctioning and pathologies. Deciphering the 3D structure of this carrier afforded a considerable progress of the knowledge but requires now additional data focused on molecular dynamics from this static picture. State of the art in this topic is reviewed and debated in this paper in view of better comprehending origin of the discrepancies in these questions and, finally, the multiple physiological roles of this carrier in eukaryotic cell economy.

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Authors and Affiliations

  1. Laboratoire de Physiologie Moléculaire et Cellulaire, Institut de Biochimie et Génétique Cellulaires-UMR 5095, CNRS-Université Bordeaux2, 1, rue Camille Saint-Saëns, 33077, Bordeaux Cedex, France

    Véronique Trézéguet & Guy J. M. Lauquin

  2. Laboratoire de Biochimie et Biophysique des Systèmes Intégrés (BBSI), Institut de Recherches en Technologies et Sciences du Vivant (iRTSV), UMR 5092, CNRS-CEA-Université Joseph Fourier, 38054, Grenoble cedex 9, France

    Ludovic Pélosi & Gérard Brandolin

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  1. Véronique Trézéguet
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  2. Ludovic Pélosi
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  3. Guy J. M. Lauquin
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  4. Gérard Brandolin
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Correspondence to Véronique Trézéguet.

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This work was supported by the University of Bordeaux2, the Région Aquitaine, the University Joseph Fourier of Grenoble, the Région Rhône-Alpes, the Commissariat à l’Energie Atomique, and the Centre National de la Recherche Scientifique.

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Trézéguet, V., Pélosi, L., Lauquin, G.J.M. et al. The mitochondrial ADP/ATP carrier: functional and structural studies in the route of elucidating pathophysiological aspects. J Bioenerg Biomembr 40, 435–443 (2008). https://doi.org/10.1007/s10863-008-9178-2

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  • DOI: https://doi.org/10.1007/s10863-008-9178-2

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