Molecular imaging scans cellular and molecular targets in living subjects through the introduction of imaging agents that bind to these targets and report their presence through a measurable signal. The picomolar sensitivity, signal stability, and high multiplexing capacity of Raman spectroscopy satisfies important needs within the field of molecular imaging, and several groups now utilize Raman and surface-enhanced Raman spectroscopy to image molecular targets in small animal models of human disease. This article details the role of Raman spectroscopy in molecular imaging, describes some substrates and imaging agents used in animal models, and illustrates some examples.

中文翻译：

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使用表面增强拉曼光谱纳米颗粒记者进行分子成像。


分子成像通过引入与这些目标结合的显像剂来扫描活体受试者中的细胞和分子目标，并通过可测量的信号报告它们的存在。拉曼光谱的皮摩尔灵敏度、信号稳定性和高复用能力满足了分子成像领域的重要需求，现在有几个研究小组利用拉曼和表面增强拉曼光谱对人类疾病小动物模型中的分子靶标进行成像。本文详细介绍了拉曼光谱在分子成像中的作用，描述了动物模型中使用的一些底物和成像剂，并举例说明了一些示例。