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Molecular imaging with surface-enhanced Raman spectroscopy nanoparticle reporters

  • Surface-enhanced Raman spectroscopy: Substrates and materials
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Abstract

Molecular imaging scans cellular and molecular targets in living subjects through the introduction of imaging agents that bind to these targets and report their presence through a measurable signal. The picomolar sensitivity, signal stability, and high multiplexing capacity of Raman spectroscopy satisfies important needs within the field of molecular imaging, and several groups now utilize Raman and surface-enhanced Raman spectroscopy to image molecular targets in small animal models of human disease. This article details the role of Raman spectroscopy in molecular imaging, describes some substrates and imaging agents used in animal models, and illustrates some examples.

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Acknowledgments

This work is funded, in part, by the NCI U54CA119367 (SSG), P50CA114747 (SSG), the Canary Foundation (SSG), and the Ben and Catherine Ivy Foundation (SSG). J.V.J. is grateful for support from the Stanford Molecular Imaging Scholars Program R25-TCA118681 and the Burroughs Wellcome Fund. J.J. was supported by a Postdoctoral Fellowship, PF-13–098–01—CCE from the American Cancer Society.

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  1. Molecular Imaging Program, Stanford University, USA

    Jesse V. Jokerst, Christoph Pohling & Sanjiv S. Gambhir

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  1. Jesse V. Jokerst
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Correspondence to Jesse V. Jokerst.

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Jokerst, J.V., Pohling, C. & Gambhir, S.S. Molecular imaging with surface-enhanced Raman spectroscopy nanoparticle reporters. MRS Bulletin 38, 625–630 (2013). https://doi.org/10.1557/mrs.2013.157

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