What is memory? How does the brain process the sensory information and modify an organism's behavior? Many neuroscientists have focused on the activity- and experience-dependent modifications of synaptic functions in order to solve these fundamental questions in neuroscience. Recently, the plasticity of intrinsic excitability (called intrinsic plasticity) has emerged as an important element for information processing and storage in the brain. As the cerebellar Purkinje cells are the sole output neurons in the cerebellar cortex and the information is conveyed from a neuron to its relay neurons by forms of action potential firing, the modulation of the intrinsic firing activity may play a critical role in the cerebellar learning. Many voltage-gated and/or Ca²⁺-activated ion channels are involved in shaping the spiking output as well as integrating synaptic inputs to finely tune the cerebellar output. Recent studies suggested that the modulation of the intrinsic excitability and its plasticity in the cerebellar Purkinje cells might function as an integrator for information processing and memory formation. Moreover, the intrinsic plasticity might also determine the strength of connectivity to the sub-cortical areas such as deep cerebellar nuclei and vestibular nuclei to trigger the consolidation of the cerebellar-dependent memory by transferring the information.

中文翻译：

---

本征可塑性的新兴概念：小脑浦肯野细胞和运动学习的内在兴奋性的活动依赖调制。

什么是记忆？大脑如何处理感官信息并改变生物体的行为？为了解决神经科学中的这些基本问题，许多神经科学家将注意力集中在依赖于活动和经验的突触功能上。最近，内在兴奋性的可塑性（称为内在可塑性）已经成为大脑中信息处理和存储的重要元素。由于小脑浦肯野细胞是小脑皮层中唯一的输出神经元，并且信息通过动作电位激发的形式从神经元传递到其中继神经元，因此内在激发活动的调节可能在小脑学习中起关键作用。许多电压门控和/或Ca ²⁺激活的离子通道参与整形加标输出以及整合突触输入以微调小脑输出。最近的研究表明，小脑浦肯野细胞内在兴奋性及其可塑性的调节可能充当信息处理和记忆形成的积分器。此外，固有的可塑性还可能决定与皮质下区域（例如小脑深核和前庭核）的连通性强度，从而通过传递信息来触发小脑依赖性记忆的巩固。