A robust and easily manufactured high-strength and long-term release hydrazone-based isoniazid acrylic (HIA) bone cement is reported. The mechanical strength of HIA bone cement is similar to that of normal polymethyl methacrylate (PMMA) bone cement, far surpassing that of traditional isoniazid-containing antibiotic-loaded bone cement (INH bone cement). Isoniazid is connected to the bone cement through bioorthogonal hydrazone chemistry, and it possesses release properties superior to those of INH bone cement, allowing for the sustained release of isoniazid for up to 12 weeks. In vivo and in vitro studies also indicate that HIA cement exhibits better biocompatibility than INH bone cement. The results of this study not only signify progress in the realm of antimicrobial bone cement for addressing bone tuberculosis but also enhance our capacity to create and comprehend high-performing antimicrobial bone cement.

中文翻译：

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基于腙键的可注射异烟肼骨水泥具有长期释放和良好的机械性能

据报道，一种坚固且易于制造的高强度、长效释放的腙基异烟肼丙烯酸（HIA）骨水泥。 HIA骨水泥的机械​​强度与普通聚甲基丙烯酸甲酯（PMMA）骨水泥相似，远远超过传统的含异烟肼抗生素骨水泥（INH骨水泥）。异烟肼通过生物正交腙化学与骨水泥连接，其释放性能优于INH骨水泥，可实现异烟肼持续释放长达12周。体内和体外研究也表明HIA骨水泥比INH骨水泥表现出更好的生物相容性。这项研究的结果不仅标志着抗菌骨水泥在解决骨结核领域取得的进展，而且增强了我们创造和理解高性能抗菌骨水泥的能力。