Injectable isoniazid-loaded bone cement based on hydrazone bonds achieving long-term release and decent mechanical properties

Yang Xu; Hao Lin; Zhe Gao; Rui Guo; Yu-chen Kan; Lu-yang Han; Wen-han Bu; Zhi Wang; Ayakuzi Asilebieke; Long-xu Han; Chuang Li; Fang He; Jian-jun Chu

doi:10.1039/D3TB02661B

Injectable isoniazid-loaded bone cement based on hydrazone bonds achieving long-term release and decent mechanical properties†

Yang Xu,

‡*^a Hao Lin,‡^c Zhe Gao,‡^b Rui Guo,^b Yu-chen Kan,^b Lu-yang Han,^b Wen-han Bu,^b Zhi Wang,^c Ayakuzi Asilebieke,^a Long-xu Han,^b Chuang Li,^d Fang He*^c and Jian-jun Chu*^bd

Author affiliations

* Corresponding authors

^a Department of Pharmaceutical Science and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, China
E-mail: xuyang@hfut.edu.cn

^b Department of Orthopedics, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230011, China
E-mail: chujianj@mail.ustc.edu.cn

^c Department of Orthopedics, Hefei BOE Hospital, Teaching Hospital of Shanghai University Medical College, Hefei, Anhui 230013, China
E-mail: hefang8@126.com

^d Institute of Advanced Technology, University of Science and Technology of China, Hefei, Anhui 230000, China

Abstract

A robust and easily manufactured high-strength and long-term release hydrazone-based isoniazid acrylic (HIA) bone cement is reported. The mechanical strength of HIA bone cement is similar to that of normal polymethyl methacrylate (PMMA) bone cement, far surpassing that of traditional isoniazid-containing antibiotic-loaded bone cement (INH bone cement). Isoniazid is connected to the bone cement through bioorthogonal hydrazone chemistry, and it possesses release properties superior to those of INH bone cement, allowing for the sustained release of isoniazid for up to 12 weeks. In vivo and in vitro studies also indicate that HIA cement exhibits better biocompatibility than INH bone cement. The results of this study not only signify progress in the realm of antimicrobial bone cement for addressing bone tuberculosis but also enhance our capacity to create and comprehend high-performing antimicrobial bone cement.

Journal of Materials Chemistry B

Injectable isoniazid-loaded bone cement based on hydrazone bonds achieving long-term release and decent mechanical properties†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Injectable isoniazid-loaded bone cement based on hydrazone bonds achieving long-term release and decent mechanical properties

Social activity

Search articles by author

Spotlight

Advertisements