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Pillar[6]MaxQ functions as an in vivo sequestrant for rocuronium and vecuronium
Chemical Communications ( IF 4.9 ) Pub Date : 2024-03-28 , DOI: 10.1039/d4cc00772g
Wanping Zhang 1 , Emmanuel A. Bazan-Bergamino 2 , Anton P. Doan 2 , Xiangjun Zhang 1 , Lyle Isaacs 2
Affiliation  

The binding affinity of pillar[6]MaxQ toward a panel of neuromuscular blockers and neurotransmitters was measured in phosphate buffered saline by isothermal titration calorimetry and 1H NMR spectroscopy. In vivo efficacy studies showed that P6MQ sequesters rocuronium and vecuronium and reverses their influence on the recovery of the train-of-four (TOF) ratio.

中文翻译:

Pillar[6]MaxQ 作为罗库溴铵和维库溴铵的体内螯合剂

通过等温滴定量热法和1 H NMR 光谱法在磷酸盐缓冲盐水中测量pillar[6]MaxQ 对一组神经肌肉阻滞剂和神经递质的结合亲和力。体内功效研究表明,P6MQ隔离罗库溴铵和维库溴铵,并逆转它们对四联 (TOF) 比率恢复的影响。
更新日期:2024-03-28
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