Issue 32, 2024
From the journal:

Chemical Communications

Pillar[6]MaxQ functions as an in vivo sequestrant for rocuronium and vecuronium†

Wanping Zhang,‡a   Emmanuel A. Bazan-Bergamino,‡b   Anton P. Doan,b   Xiangjun Zhang*a  and  Lyle Isaacs ORCID logo *b  

* Corresponding authors

a College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. China
E-mail: xiangjunzhang@cqmu.edu.cn

b Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA
E-mail: LIsaacs@umd.edu

Abstract

The binding affinity of pillar[6]MaxQ toward a panel of neuromuscular blockers and neurotransmitters was measured in phosphate buffered saline by isothermal titration calorimetry and 1H NMR spectroscopy. In vivo efficacy studies showed that P6MQ sequesters rocuronium and vecuronium and reverses their influence on the recovery of the train-of-four (TOF) ratio.

Graphical abstract: Pillar[6]MaxQ functions as an in vivo sequestrant for rocuronium and vecuronium

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Article information

DOI
https://doi.org/10.1039/D4CC00772G
Article type
Communication
Submitted
16 Feb 2024
Accepted
20 Mar 2024
First published
28 Mar 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 4350-4353

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Pillar[6]MaxQ functions as an in vivo sequestrant for rocuronium and vecuronium

W. Zhang, E. A. Bazan-Bergamino, A. P. Doan, X. Zhang and L. Isaacs, Chem. Commun., 2024, 60, 4350 DOI: 10.1039/D4CC00772G

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