In this study, we developed an adenoviral-vectored vaccine that targets the spike protein of BA.5 Omicron SARS-CoV-2. When nasally delivered in mice and hamsters, the vaccine stimulated mucosal antibody production and CD8+ T cell responses, and demonstrated protection against several SARS-CoV-2 strains, including the antigenically distant Omicron XBB.1.5 strain. Immune cell depletion studies showed that cross-reactive memory CD8+ T cells contribute to the cross-protection that is conferred by nasal vaccines against respiratory infection with antigenically shifted SARS-CoV-2 Omicron strains.

中文翻译：

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鼻疫苗可引发针对抗原转移 SARS-CoV-2 病毒的保护性 CD8+ T 细胞免疫

在这项研究中，我们开发了一种腺病毒载体疫苗，针对 BA.5 Omicron SARS-CoV-2 的刺突蛋白。当经鼻注射到小鼠和仓鼠体内时，该疫苗刺激了粘膜抗体的产生和 CD8+ T 细胞反应，并表现出对多种 SARS-CoV-2 毒株的保护作用，包括抗原性较远的 Omicron XBB.1.5 毒株。免疫细胞耗竭研究表明，交叉反应记忆 CD8+ T 细胞有助于鼻疫苗针对抗原转移的 SARS-CoV-2 Omicron 菌株呼吸道感染所提供的交叉保护。