Intratumoral regulatory T (Treg) cells can suppress antitumor immunity. Unlike in splenic Treg cells, the H3K9me2 demethylase JMDJ1 seems to be induced, and is required for this function, in the tumor microenvironment, and targeting it with a small-molecule inhibitor can suppress tumor growth in mice.

中文翻译：

---

通过抑制 JMJD1C 重新激活抗肿瘤免疫

瘤内调节性 T (Treg) 细胞可以抑制抗肿瘤免疫。与脾 Treg 细胞不同，H3K9me2 去甲基化酶 JMDJ1 似乎是在肿瘤微环境中被诱导的，并且是该功能所必需的，并且用小分子抑制剂靶向它可以抑制小鼠中的肿瘤生长。