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Cancer immunology

Reactivating antitumor immunity by inhibiting JMJD1C

Nature Immunology volume 25, pages 390–391 (2024)Cite this article

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Intratumoral regulatory T (Treg) cells can suppress antitumor immunity. Unlike in splenic Treg cells, the H3K9me2 demethylase JMDJ1 seems to be induced, and is required for this function, in the tumor microenvironment, and targeting it with a small-molecule inhibitor can suppress tumor growth in mice.

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Fig. 1: JMJD1C promotes IFNγ expression in intratumor Treg cells.

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Authors and Affiliations

  1. Laboratory of Epigenome Biology, Systems Biology Center, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

    Xuezheng Wang & Keji Zhao

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  1. Xuezheng Wang
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  2. Keji Zhao
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Correspondence to Keji Zhao.

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The authors declare no competing interests.

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Wang, X., Zhao, K. Reactivating antitumor immunity by inhibiting JMJD1C. Nat Immunol 25, 390–391 (2024). https://doi.org/10.1038/s41590-024-01760-w

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