This research elucidates that oligodendrocytes detect and respond to fast axonal spiking through K+ signaling, and that Kir4.1 channel activation has a pivotal role. This activity-driven interaction regulates axonal metabolic support by oligodendrocytes and influences lactate delivery and glucose metabolism in axons, which is essential for sustaining axonal health.

中文翻译：

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K+ 动力学驱动的有髓轴突的少突胶质细胞代谢支持

这项研究阐明少突胶质细胞通过 K+ 信号传导检测和响应快速轴突尖峰，而 Kir4.1 通道激活具有关键作用。这种活动驱动的相互作用通过少突胶质细胞调节轴突代谢支持，并影响轴突中的乳酸输送和葡萄糖代谢，这对于维持轴突健康至关重要。