Amine-cured epoxy resins bearing ester moieties were synthesized, and their properties, hydrolytic degradation behavior, and biomineralization were investigated. Neopentyl glycol diglycidate (NPG) was used as the epoxide and was cured with diethylenetriamine (DETA) and isophoronediamine (IPD) at different ratios. The glass transition temperatures were controlled using the composition of DETA and IPD. The cured materials containing IPD units were tolerant to neutral water but were degraded under acidic and basic conditions. Degradation in the presence of lipase also proceeded in phosphate buffer, while degradation proceeded gradually in the absence of lipase. To demonstrate their potential application as degradable biomedical materials for bone and dental repair, composites containing hydroxyapatite (HA) were prepared by curing NPG and the amines in the presence of HA. Biological bone-like apatite was grown on an NPG-IPD-HA composite by immersion in synthetic biofluid, and the amount of bone-like apatite was greater than that on the glycidyl ether analog.

合成了带有酯部分的胺固化环氧树脂，并研究了它们的性能、水解降解行为和生物矿化。新戊二醇二缩水甘油酯（NPG）用作环氧化物，并用不同比例的二乙烯三胺（DETA）和异佛尔酮二胺（IPD）进行固化。使用 DETA 和 IPD 的组合物控制玻璃化转变温度。含有IPD单元的固化材料耐中性水，但在酸性和碱性条件下会降解。在存在脂肪酶的情况下，降解也在磷酸盐缓冲液中进行，而在不存在脂肪酶的情况下，降解逐渐进行。为了证明其作为可降解生物医学材料用于骨骼和牙齿修复的潜在应用，通过在 HA 存在下固化 NPG 和胺来制备含有羟基磷灰石 (HA) 的复合材料。通过浸入合成生物流体中，在 NPG-IPD-HA 复合材料上生长生物骨状磷灰石，并且骨状磷灰石的量大于缩水甘油醚类似物上的量。