RSC主编推荐：有机领域精彩文章快览（免费阅读原文）

英国皇家化学会（RSC）是一个拥有175年历史的面向全球化学家的非营利会员制机构，旗下拥有43种期刊，其中很多在化学领域有很高影响力。为了进一步帮助广大读者追踪科技前沿热点，X-MOL团队与英国皇家化学会合作，推出英国皇家化学会期刊主编推荐的精彩文章快览，本期文章属“有机领域”，英文点评来自英国皇家化学会期刊的主编。如果大家对我们的解读有更多的补充和点评，欢迎在文末写评论发表您的高见！

Organic Chemistry Frontiers (IF: 4.955)

1. A benzothiadiazole-based fluorescent sensor for selective detection of oxalyl chloride and phosgene

Org. Chem. Front., 2017, Advance Article

DOI: 10.1039/C7QO00378A

Oxalyl chloride and phosgene are highly toxic chemicals but are widely used in industrial processes, which have been regarded as a serious threat to our health and public security. Thus, it is imperative to develop a convenient and reliable detection method for these noxious agents. It was reported in this research the rational design of a fluorescent sensor (denoted as BTA) for simultaneously detecting oxalyl chloride and phosgene, in which o-phenylenediamine (OPD) as the reactive recognition site and benzothiadiazole (BTD) as the fluorophore moiety are coupled into one single benzo-fused motif. The probe works in a “turn-on” fluorescence mode due to the formation of piperazine-2,3-dione and 2-imidazolidinone rings by intramolecular cyclization reactions between the OPD part with oxalyl chloride and phosgene, respectively, which greatly inhibits the intramolecular charge transfer (ICT) process from two amines to the BTD core in the sensor BTA. The detection limit of oxalyl chloride and phosgene is as low as 3 nM and 20 nM in solutions, respectively. Moreover, the sensor exhibits outstanding selectivity toward oxalyl chloride and phosgene over the nerve-agent mimic diethyl chlorophosphate and various acyl chlorides. Furthermore, a portable test paper with BTA has been facilely fabricated for visual on-site detection of the two toxic chemicals in the gas phase.

剧毒化学品草酰氯和光气在工业生产中有着广泛的应用，被看作是人类健康和公共安全的严重威胁。因此，对这些有害物质开展方便可靠的检测方法势在必行。在本论文中，江苏师范大学的李秋艳、王晓军及其合作者报道了一种用于同时检测草酰氯和光气的荧光探针分子（表示为BTA）的合理设计方法，其中作为反应识别位点的邻苯二胺（OPD）和作为荧光基团的苯并噻二唑（BTD）偶联形成单一的苯并稠合单元。该探针的OPD基团可与草酰氯或光气分别发生分子内环化反应，生成哌嗪-2,3-二酮或2-咪唑啉酮环，从而极大地抑制了从两个氨基到BTD核心的分子内电荷转移（ICT）过程，开启探针分子的“turn-on”荧光模式。草酰氯和光气在溶液中的检测限分别可低至3 nM和20 nM。而且，相比于神经毒剂类似物二乙基磷酰氯以及多种酰氯，该传感器对草酰氯和光气具有优异的选择性。此外，带有BTA的便携试纸可方便地制得，用于气相中两种有毒化学物质的现场检测。

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2. Transition-metal-free dehydrogenation coupling of pyridinium through a self-promoted hydride transfer process

Org. Chem. Front., 2017, Advance Article

DOI: 10.1039/C7QO00389G

A transition-metal-free intramolecular cross dehydrogenation coupling reaction of pyridinium was developed. The C(sp²)–H/C(sp²)–H coupling reaction involved an unprecedented intermolecular hydride transfer process from the 1,2-dihydropyridine intermediate to another molecule of pyridinium and formed 1,4-dihydropyridine. Unlike the well-known dehydrogenation coupling proceeded under oxidative conditions, this was the first example of the coupling reaction through a substrate self-promoted hydride transfer process.

云南大学的夏成峰教授及其团队成功开发了一种无过渡金属参与的吡啶鎓分子内交叉脱氢偶联反应。C(sp²)-H/C(sp²)-H键的偶联反应涉及从1,2-二氢吡啶中间体到另一吡啶鎓分子分子间负氢转移的罕见过程，生成1,4-二氢吡啶产物。与人们熟知的氧化条件下进行脱氢偶联的反应有所不同，这是首例通过底物自促进负氢转移过程进行的偶联反应。

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Chemical Science (IF: 8.668)

1. Using highly emissive and environmentally sensitive o-carborane-functionalized metallophosphors to monitor mitochondrial polarity

Chem. Sci., 2017, Advance Article

DOI: 10.1039/C7SC00160F

Scientists in Nanjing designed and synthesized highly emissive and environmentally sensitive phosphorescent iridium(II) complexes functionalized by o-carborane. One complex was found to be an efficient polarity-sensitive phosphorescent probe, which exhibited a visual colour change as a function of polarity and unique mitochondria affinity. This complex was able to track cell apoptosis and distinguish cancer cells from normal cells, by photoluminescence imaging microscopy.

南京大学的燕红、芦昌盛和南京邮电大学的赵强等研究者设计并合成了高发射性、环境敏感的邻碳硼烷官能化的Ir(II)磷光络合物。研究人员发现其中的一个络合物是一种有效的极性敏感磷光探针，具有独特的线粒体亲和力，还可随极性的不同而发生可见色彩变化。在光致发光成像显微镜检测中，该络合物可用于以跟踪细胞凋亡以及区分癌细胞与正常细胞。

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2. Single operation palladium catalysed C(sp³)-H functionalisation of tertiary aldehydes: investigations into transient imine directing groups

Chem. Sci., 2017, Advance Article

DOI: 10.1039/C7SC01218G

UK researchers have shown that a variety of simple amine derivatives promoted the palladium catalysed direct β-C-H arylation of aliphatic aldehydes. The amine derivatives formed transient imine directing groups to encourage aldehyde C-H arylation, in a single synthetic operation. These findings could be useful for the future development of directing groups to be formed transiently to promote C-H functionalisation.

英国伦敦帝国理工学院的研究人员报道了一系列简单的胺类衍生物促进的脂肪醛在钯催化下的直接β-C-H键芳基化反应。在单次的合成操作中，胺类衍生物形成瞬态亚胺导向基团促进醛的C-H键芳基化。这些发现有助于在将来进一步开发瞬态形成的导向基团，以促进C-H键官能化反应的研究。

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