The widely existing transmembrane helices can serve as a novel type of binding site for recognizing corresponding membrane receptors. Through imprinting the transmembrane domain of certain receptors, here we report the construction of polymeric nanoparticles which can achieve enhanced cellular uptake and permeability in target tissues for tumor-targeted drug delivery.

中文翻译：

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通过压印膜受体的“隐藏”部分以靶向药物递送，增强纳米颗粒的细胞摄取和肿瘤渗透

广泛存在的跨膜螺旋可用作识别相应膜受体的新型结合位点。通过印迹某些受体的跨膜结构域，我们在此报道了聚合物纳米颗粒的构建，该聚合物纳米颗粒可在肿瘤靶向药物输送的靶组织中实现增强的细胞摄取和渗透性。